Inner Secrets of the Respirasome
نویسندگان
چکیده
Structure determination by cryo-electron microscopy has approached atomic resolution and helped solve structures of large membrane-protein complexes that resisted crystallography. The 4.0 Å cryo-EM structure of one of the most intricate enzyme systems, the respirasome, in the mitochondrial inner membrane is reported in this issue of Cell.
منابع مشابه
Functional asymmetry and electron flow in the bovine respirasome
Respirasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner mitochondrial membrane. We determined the structure of supercomplex I1III2IV1 from bovine heart mitochondria by cryo-EM at 9 Å resolution. Most protein-protein contacts between complex I, III and IV in the membrane are mediated by supernumerary subunits. Of the two Rieske iron-sulfur cluster...
متن کاملInteraction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography.
The respirasome is a multisubunit supercomplex of the respiratory chain in mitochondria. Here we report the 3D reconstruction of the bovine heart respirasome, composed of dimeric complex III and single copies of complex I and IV, at about 2.2-nm resolution, determined by cryoelectron tomography and subvolume averaging. Fitting of X-ray structures of single complexes I, III(2), and IV with high ...
متن کاملمسؤولیت مدنی ناشی از افشای اسرار پزشکی در حقوق ایران و کامنلا
Revealing medical secrets is one of the most important topics in medical law, and has an ancient root in medical history and morality. Keeping patients' secrets is one of the certain laws in internal and international laws and regulations of the most countries that have been recognized in patients' bill of rights. Keeping patients' secrets causes patients to confide in physicians and refer to t...
متن کاملCOX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation
The COX7A2L (Supercomplex Assembly Factor I, SCAFI) protein has been proposed to be a mitochondrial supercomplex assembly factor required for respirasome (supercomplex containing complexes I, III, and IV) formation. In the C57BL/6 mouse strain a homozygous in-frame 6-base-pair deletion in the COX7a2l/SCAF1 gene resulting in unstable protein and suggesting loss of function was previously identif...
متن کاملAnalyzing the problem of meaning in Shabastari’s Golshane Raz
Man has always been finding a complete model for semantics since the beginning. A model which can as a paradigm affects all branches of sciences. In the view of author, such a model can be found in Golshane Raz. Introducing the model from the work mentioned, the paper has tried to explain its sub structural foundations in three fields of ontology, epistemology and semantics. Some of the foundat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 167 شماره
صفحات -
تاریخ انتشار 2016